1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID

1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID - Names and Identifiers

Name	1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
Synonyms	3-amino-4-anilino-2-benzopyran-1-one 1,5-diphenyl-1H-pyrazole-3-carboxylate 1,5-di(phenyl)-3-pyrazolecarboxylic acid 1,5-di(phenyl)pyrazole-3-carboxylic acid 1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid 1H-pyrazole-3-carboxylic acid, 1,5-diphenyl- 1H-Pyrazole-3-carboxylic acid, 1,5-diphenyl-
CAS	13599-22-9
InChI	InChI=1/C16H12N2O2/c19-16(20)14-11-15(12-7-3-1-4-8-12)18(17-14)13-9-5-2-6-10-13/h1-11H,(H,19,20)/p-1

1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C16H12N2O2
Molar Mass	264.28
Density	1.23±0.1 g/cm3(Predicted)
Melting Point	183 °C(Solv: water (7732-18-5))
Boling Point	496.2±33.0 °C(Predicted)
Flash Point	253.9°C
Vapor Presure	1.16E-10mmHg at 25°C
pKa	3.86±0.10(Predicted)
Storage Condition	2-8°C

1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID - Risk and Safety

Risk Codes

22 - Harmful if swallowed

1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID - Introduction

1,5-Diphenyl-1H-pyrazole-3-carboxylic acid is an organic compound with the chemical formula C16H13NO2.

Nature:
1,5-Diphenyl-1H-pyrazole-3-carboxylic acid is a white solid, soluble in some organic solvents, such as ethanol and dichloromethane. It has a lower melting and boiling point.

Use:
1,5-Diphenyl-1H-pyrazole-3-carboxylic acid is widely used as a pharmaceutical intermediate, especially in drug development. The pyrazole ring in its structure has biological activity and can be used to synthesize antibacterial drugs, anti-tumor drugs and other drugs. In addition, it can also be used as a synthetic raw material for dyes and photosensitizers.

Preparation Method:
The preparation of 1,5-diphenyl-1H-pyrazole-3-carboxylic acid can be obtained by acylation reaction of pyrrole and phenylboronic acid. First, pyrrole and phenylboronic acid are added to a reaction flask, and an acidic catalyst, such as boric acid or phosphoric acid, is added. Then, the reaction is carried out at an appropriate temperature and reaction time to finally obtain a product. After completion of the reaction, the product is purified by purification and crystallization techniques.

Safety Information:
1,5-diphenyl-1H-pyrazole-3-carboxylic acid needs to be safe during use and handling. It may be irritating to the eyes, skin and respiratory tract and contact with them should be avoided. In industrial production, appropriate protective measures should be taken, such as wearing protective glasses, gloves and masks. When stored, it should be kept in a sealed container, away from fire and oxidizing agents. If inhaled or exposed to the compound, get medical help immediately and treat according to the specific situation.

Last Update：2024-04-09 21:01:54